Figure 4. Sodium iodate (SI) exposure causes less cell death in retinal pigment epithelium cells isolated from calcium-indepent phospholipase
A2 (iPLA2-VIA) KO mice compared to wild-type mice. Primary RPE cultures were exposed to 2 mM of SI for 24 h. A significant discrepancy
was seen in SI-induced cell death in KO compared to WT mice. Hence, 2 mM SI induced 56% cell death, whereas only 15% cell
death was seen in the KO mice. WT, iPLA2-VIA wild-type mice; KO, iPLA2-VIA KO mice; *** indicates p<0.001 ± SD (n=8).