Figure 4. Sodium iodate (SI) exposure causes less cell death in retinal pigment epithelium cells isolated from calcium-indepent phospholipase A² (iPLA₂-VIA) KO mice compared to wild-type mice. Primary RPE cultures were exposed to 2 mM of SI for 24 h. A significant discrepancy was seen in SI-induced cell death in KO compared to WT mice. Hence, 2 mM SI induced 56% cell death, whereas only 15% cell death was seen in the KO mice. WT, iPLA₂-VIA wild-type mice; KO, iPLA₂-VIA KO mice; *** indicates p<0.001 ± SD (n=8).