Figure 1. Sodium iodate (SI) induces retinal pigment epithelium cell death in a dose- and time-dependent manner. A: Percent ARPE-19 cell death after 24 h of exposure to different doses of SI. Black bars indicate nonconfluent cells, and blue bars indicate confluent cells. * indicates p<0.05 (0.5 mM SI, n=5; 0.75 mM SI, n=3; 1 mM SI, n=5; 2 mM SI, n=3; 5 mM SI, n=2) when cell death is compared between nonconfluent and confluent ARPE-19 cells. B: Percent cell death of ARPE-19 cells after exposure to 1 mM SI for 2 h, 24 h, and 48 h in nonconfluent and confluent cells. Black bars indicate nonconfluent cells, and blue bars indicate confluent cells. * indicates p<0.05 ± SD (n=3) when cell death is compared between nonconfluent and confluent ARPE-19 cells. # indicates p<0.01± SD (n=3) when cell death is compared between 2 h SI treatment compared to 24 and 48 h. C: Percent cell death in mouse primary RPE cells after exposure to different doses of SI. Cells were exposed to SI for 24 h.