Figure 2. Therapeutic intervention for neovascular age-related macular degeneration from a tissue repair perspective. Complete repair requires an adequate blood supply. Our current approach leads to arrest of repair secondary to vascular destruction or compromise of vascular growth and therefore the inability of the macula to progress through the normal stages to repair for complete healing. Pro-angiogenic and vasculogenic strategies lead to accelerated neovascular maturation, cessation of vascular leakage, resolution of hypoxia, and prevention of excessive fibrosis to ultimately preserve photoreceptors and maintain vision. PDT=photodynamic therapy.