Molecular Vision: Yang, Mol Vis 2014; 20:200-214. Table 5

Table 5. Association analysis of polymorphisms in multivariate models

Gene	SNP	genotype	Ajusted OR (CI)	P value
KDR	rs2071559	TT		0.05
		CT	1.57 (1.01,2.44)
		CC	1.87 (1.01,3.48)
	rs1870377	TT		0.64
		TA	1.13 (0.69,1.85)
		AA	0.88 (0.48,1.6)
	rs1870378	GG		0.79
		GA	1.1 (0.66,1.81)
		AA	0.91 (0.5,1.66)
	rs13109660	GG		0.93
		GA	1.01 (0.48,2.13)
		AA	1.09 (0.7,1.68)
VEGF	rs699947	CC		0.002
		CA	1.26 (0.82,1.95)
		AA	3.74 (1.75,8.00)
	rs833061	TT		0.004
		CT	1.19 (0.77,1.85)
		CC	3.50 (1.62,7.54)
	rs13207351	GG		0.002
		GA	1.22 (0.79,1.89)
		AA	3.64 (1.71,7.77)
	rs2146323	CC		0.014
		CA	1.14 (0.73,1.77)
		AA	2.88 (1.4,5.93)
	rs3025021	TT
		CT	0.75 (0.2,2.78)	0.22
		CC	1.14 (0.32,4.06
	rs833069	GG
		GA	1.09 (0.63,1.89)	0.63
		AA	1.3 (0.73,2.34)
	rs2010963	GG
		GC	0.89 (0.56,1.41)	0.51
		CC	0.7 (0.38,1.28)
	rs3025039	CC		0.23
		CT	1.23 (0.79,1.92)
		TT	2.8 (0.76,10.27)
ICAM-1	rs5498	AA		0.091
		GA	1.44 (0.94,2.22)
		GG	2.04 (0.94,4.44)
EPO	rs507392	TT		0.88
		CT	1.02 (0.65,1.61)
		CC	0.8 (0.32,2.02)
	rs551238	AA		0.94
		CA	1.07 (0.67,1.68)
		CC	0.92 (0.36,2.36)
	rs1617640	TT
		GT	0.85 (0.53,1.36)	0.79
		GG	0.94 (0.36,2.41)
AKR1B1	759853	GG		0.11
		GA	0.62 (0.39,0.99)
		AA	0.59 (0.17,2.05)
ACE	1800764	TT		0.33
		CT	0.87 (0.56,1.37)
		CC	0.62 (0.33,1.16)
	rs9896208	CC
		TC	0.62 (0.39,0.97)	0.097
		TT	0.88 (0.47,1.63)
PRK-β	3900007	AA		0.82
		GA	1.14 (0.72,1.8)
		GG	1.17 (0.64,2.14)
	2575390	CC		0.78
		CG	0.89 (0.46,1.71)
		GG	2.73 (0.1,73.85)
	3760106	GG		0.81
		GA	2.67 (0.1,71.35)
		AA	0.92 (0.48,1.77)

Multiple logistic regression analysis was used to calculate odds ratio (OR) and 95% confidence interval (CI) by comparing diabetic retinopathy (DR) group with diabetic without retinopathy (DWR) group, which include the most significant SNP at kinase insert domain receptor gene (KDR) gene (rs2071559), vascular endothelial growth factor (VEGF) gene (rs833061, rs13207351, rs699947, rs2146323). Adjusted OR represents data after adjustment for covariates including age of diabetic onset, duration, high albuminuria, insulin use, glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose and creatinine levels.