Table 1 of
Yang, Mol Vis 2014; 20:200-214. Table 1 of
Yang, Mol Vis 2014; 20:200-214.
Table 1. Description of candidate genes investigated
| Gene | Gene function | Locus | References |
|---|---|---|---|
| PPARγ | responsible for differentiation of fibroblasts to adipocytes and regulation of their function | 3p25 | Maciej et al. 2008 [13] |
| KDR | functions as the main mediator of VEGF-induced endothelial permeability, proliferation, survival, migration, tubular morphogenesis and sprouting | 4q11-q12 | Galan et al. 2010 [46] |
| VEGF | a critical angiogenic and vasopermeability factor that is upregulated in various conditions involving retinal ischemia | 6p12 | Churchill et al. 2008 [15] Al-Kateb et al. 2007 [16] |
| EPO | been linked to angiogenesis, vasculogenesis, and neuroprotection | 7q21–7q22 | Tong et al. 2008 [18] Abhary et al. 2010 [19] |
| AKR1B1 | the first and rate-limiting enzyme in the polyol pathway | 7q35 | Richeti, F et al. 2007 [22] Abhary et al. 2009 [23] |
| PKC-β | PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways | 16p11.2 | Uthra et al. 2010 [24] Ikeda et al. 2004 [25] |
| ACE | involved in the conversion of angiotensin I to angiotensin II (ATII). | 17q23 | Kondo et al. 2009 [26] |
| ICAM-1 | a member of the immunoglobulin superfamily of adhesion molecules, involved in blood-retina barrier breakdown, capillary nonperfusion and endothelial cell damage and death | 19p13 | Kamiuchi, et al. 2002 [21] L. Liu, et al. 2006 [22] Petrovic, et al. 2008 [23] |