Table 1 of Yang, Mol Vis 2014; 20:200-214.

Table 1. Description of candidate genes investigated

Gene Gene function Locus References
PPARγ responsible for differentiation of fibroblasts to adipocytes and regulation of their function 3p25 Maciej et al. 2008 [13]
KDR functions as the main mediator of VEGF-induced endothelial permeability, proliferation, survival, migration, tubular morphogenesis and sprouting 4q11-q12 Galan et al. 2010 [46]
VEGF a critical angiogenic and vasopermeability factor that is upregulated in various conditions involving retinal ischemia 6p12 Churchill et al. 2008 [15]
Al-Kateb et al. 2007 [16]
EPO been linked to angiogenesis, vasculogenesis, and neuroprotection 7q21–7q22 Tong et al. 2008 [18]
Abhary et al. 2010 [19]
AKR1B1 the first and rate-limiting enzyme in the polyol pathway 7q35 Richeti, F et al. 2007 [22]
Abhary et al. 2009 [23]
PKC-β PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways 16p11.2 Uthra et al. 2010 [24]
Ikeda et al. 2004 [25]
ACE involved in the conversion of angiotensin I to angiotensin II (ATII). 17q23 Kondo et al. 2009 [26]
ICAM-1 a member of the immunoglobulin superfamily of adhesion molecules, involved in blood-retina barrier breakdown, capillary nonperfusion and endothelial cell damage and death 19p13 Kamiuchi, et al. 2002 [21]
L. Liu, et al. 2006 [22]
Petrovic, et al. 2008 [23]