Figure 2. Correlation between retinitis pigmentosa severity and rhodopsin stability. The relationship between the age of onset and the
stability of rhodopsin variants with mutations in intradiscal residues is shown (top). There is a strong correlation between
∆∆G and the severity of visual function in the youngest cohort (0–29 years, center), but in the older cohorts, other factors
play an increasingly influential role in clinical severity, and the correlation is reduced or completely masked (bottom).