Figure 5. Reactive oxygen species (ROS) signal expression 24 h after lipopolysaccharide injection is shown. ROS signal (red) was weak
in the A: naïve eyes. B: ROS signal was reduced by echinochrome treatment compared with C: iris/ciliary body (ICB) tissue of untreated endotoxin induced uveitis (EIU) rats, in which ROS signal was strongly expressed.
D: Mean gray values of the corneal epithelium in dihydroethidium (DHE)-stained slides of the ICB area were evaluated. Mean
gray values were significantly lower in the ICB of rats treated with echinochrome than in the eyes of untreated EIU controls
(p<0.05). Data are shown as mean ± standard error of the mean (SEM; n=4). *Mean gray value of echinochrome treated eyes was
significantly lower than untreated EIU controls (p<0.05).