Figure 8. Outer nuclear layer thickness in Pde6b^rd10/rd10 mice after later (age P17-P28) and early (age P9-P21) systemic valproic acid (VPA) treatment. Spiderogram graphs of outer nuclear layer (ONL) thickness measured from periphery to periphery in Pde6b^rd10/rd10 mice treated with systemic VPA or PBS (control littermates). A: Slightly thinner ONL in VPA-treated Pde6b^rd10/rd10 mice compared to PBS-treated littermates at age P28, after late dosing (age P17-P28; n = 4 VPA, 3 PBS; t test, *p<0.05, **p<0.01, relative to PBS). B: ONL thickness in VPA-treated and PBS-treated littermates at age P21, after early treatment (age P9–P21) (n = 3 VPA, 4 PBS; t test, *p<0.05, **p<0.01, relative to PBS).