Figure 6. Full-field (ganzfeld) ERG testing of Pde6b^rd10/rd10 mice treated with systemic valproic acid (VPA; P17–P28, later treatment). Bilateral full-field electroretinography (ERG) testing was completed on dark-adapted mice at age P27. A: Graph of the dark-adapted B-wave amplitudes from VPA-treated (n = 3) and PBS-treated (n = 2) littermates (mean±standard deviation) at age P27. Amplitudes for each individual were calculated as an average of both eyes. VPA-treated mice had reduced amplitudes relative to PBS-treated controls over the range shown. B: Examples of bilateral full-field ERG traces from VPA-treated and PBS-treated littermates for the dome flash intensity of 4 cd-sec/m². ERG responses were similar between contralateral eyes.