Molecular Vision: Hoang, Mol Vis 2014; 20:1491-1517. Table 2

Table 2. Expression of tyrosine kinase receptors in epithelial cells and fiber cells.

Gene symbol	Description	F_RPKM	E_RPKM	F_counts	E_counts	FC*	P value
Fgfr3	Fibroblast growth factor receptor 3	121.86	135.8	9683.7	3695.2	2.62	3.85E-16
Fgfr2	Fibroblast growth factor receptor 2	30.09	74.3	1764.3	1624.6	1.09	1
Fgfr1	Fibroblast growth factor receptor 1	27.77	64.9	2228.2	1894.7	1.18	0.424884574
Ddr1	Discoidin domain receptor family, member 1	26.72	114.4	2436.2	3987.0	−1.64	4.74E-05
Epha2	Eph receptor A2	14.89	16.7	1223.4	496.3	2.46	0.000111118
Ephb3	Eph receptor B3	8.65	18.4	414.7	356.8	1.16	0.717922501
Ryk	Receptor-like tyrosine kinase	7.95	21.1	619.7	626.3	−1.01	1
Igf1r	Insulin-like growth factor 1 receptor	6.79	24.37	862.5	1108	−0.77	0.17
Insr	Insulin receptor	3.99	13.6	932.0	1144.6	−1.23	0.283411755
Pdgfra	Platelet derived growth factor receptor, alpha	3.91	96.0	720.3	6218.4	−8.63	1.22E-19
Met	Met proto-oncogene	2.92	0.6	162.8	27.3	5.95	3.26E-11
Erbb4	Epidermal growth factor receptor 4	2.23	6.8	663.2	821.7	−1.24	0.290412165
Epha5	Eph receptor A5	1.74	5.1	204.3	237.0	−1.16	0.993890715
Ror1	Receptor tyrosine kinase-like orphan receptor 1	1.53	14.7	246.2	885.9	−3.60	0.000237418
Ephb2	Eph receptor B2	1.47	7.7	204.0	391.8	−1.92	0.000338882
Ephb4	Eph receptor B4	1.07	21.6	119.3	867.7	−7.28	1.82E-35
Erbb2	Epidermal growth factor receptor 2	1.03	10.5	137.3	431.7	−3.15	5.82E-10
Ptk7	PTK7 protein tyrosine kinase 7	0.85	19.3	100.7	845.8	−8.40	6.54E-24
Tek	Endothelial-specific receptor tyrosine kinase	0.81	15.1	78.6	705.3	−8.97	1.06E-36
Ntrk2	Neurotrophic tyrosine kinase, receptor, type 2	0.38	5.1	75.5	398.2	−5.27	0.120798265
Ret	Ret proto-oncogene	0.36	0.2	73.3	15.9	4.61	6.03E-05
Pdgfrb	Platelet derived growth factor receptor, beta	0.30	6.8	45.1	377.4	−8.38	9.25E-24
Ephb1	Eph receptor B1	0.20	0.6	23.9	33.2	−1.39	1
Epha4	Eph receptor A4	0.16	0.5	27.8	33.6	−1.21	0.992147532
Axl	AXL receptor tyrosine kinase	0.13	10.7	6.1	356.0	−58.32	1.93E-24
Ephb6	Eph receptor B6	0.13	1.8	6.0	66.2	−11.04	6.75E-07
Erbb3	Epidermal growth factor receptor 3	0.05	0.3	9.2	14.8	−1.60	0.762104733
Ntrk1	Neurotrophic tyrosine kinase, receptor, type 1	0.04	0.4	6.6	9.2	−1.38	0.972770678
Epha7	Eph receptor A7	0.04	1.8	2.1	59.0	−28.45	1.29E-06
Epha8	Eph receptor A8	0.04	0.0	5.5	1.3	4.12	0.554412732
Musk	Muscle, skeletal, receptor tyrosine kinase	0.03	0.0	3.1	0.2	20.15	0.595515715
Epha10	Eph receptor A10	0.03	0.5	1.1	21.1	−19.10	0.004189458
Kdr	Kinase insert domain protein receptor	0.03	11.5	4.4	708.8	−161.25	1.15E-29
Flt4	FMS-like tyrosine kinase 4	0.03	2.3	5.0	145.7	−29.20	4.33E-19
Egfr	Epidermal growth factor receptor	0.02	0.6	1.7	37.2	−22.34	2.53E-05
Tie1	Tyrosine kinase receptor 1	0.02	8.7	1.6	384.3	−237.81	5.23E-10
Ltk	Leukocyte tyrosine kinase	0.02	0.0	1.0	0.0	inf	0.992147532
Ror2	Receptor tyrosine kinase-like orphan receptor 2	0.02	2.3	1.6	91.5	−56.61	0.005034625
Epha3	Eph receptor A3	0.01	0.2	1.1	12.7	−11.52	0.087755426
Fgfr4	Fibroblast growth factor receptor 4	0.01	0.3	1.2	9.1	−7.76	0.232438017
Epha1	Eph receptor A1	0.01	0.7	1.5	24.3	−16.72	0.003364677
Flt1	FMS-like tyrosine kinase 1	0.00	8.5	0.6	566.8	−962.19	6.66E-83
Ntrk3	Neurotrophic tyrosine kinase, receptor, type 3	0.00	0.1	0.0	1.7	0.00	0.981954195
Epha6	Eph receptor A6	0.00	0.2	0.0	4.6	0.00	0.393262883
Ddr2	Discoidin domain receptor family, member 2	0.00	0.6	0.0	59.0	0.00	0.005585263

Genes were ranked based on the RPKM (Reads Per Kilobase per Million mapped reads) values in the fiber cells (F) with F counts and E counts representing normalized read counts from DESeq software from the fiber and epithelial cell samples, respectively. *Fold-change (FC) was based on the expression level in the fiber cells relative to the epithelial cells in normalized counts produced by DESeq. Negative values indicate expression lower in the fiber cells compared with the epithelial cells. Genes with a p-adjusted value less than 0.05 and more than a 1.5 fold-change in normalized read counts were considered as differential expression.