Figure 4. No effects of goggling on DA metabolism in Vsx1+/+ and Vsx1−/− mice: A: Following 4 (C57Bl/6J mice) or 8 (Vsx1+/+ and Vsx1−/− mice) weeks of form deprivation (FD), the ratio of the right eye to the left eye (the OD/OS ratio) for retinal 3,4-dihydroxyphenylacetate (DOPAC) was not significantly different between the goggled and control animals for any strain or genotype (two-way ANOVA interaction effect, F(2,29)=0.545, p=0.587). B: The OD/OS ratio for retinal dopamine (DA) was also similar between the treatment groups for all mouse groups (two-way ANOVA interaction effect, F(2,29)=0.015, p=0.985). C: FD did not cause significant changes in the DOPAC/DA ratios of the goggled animals compared to the untreated naïve controls for any genotype or strain (two-way repeated-measures ANOVA, F(2,29)=0.781, p=0.469). Data are expressed as the mean ± standard error of the mean (SEM). Animal numbers used for analysis: Vsx1+/+ (control, n=6; goggled n=3), Vsx1−/− (control, n=7; goggled n=4), and C57BL/6J mice (control, n=6; goggled n=4).