Figure 3. Higher retinal dopamine turnover in 129S1/Sv mice compared to C57BL/6J: A: At 4 weeks of age, the 3,4-dihydroxyphenylacetate (DOPAC) levels in the Vsx1−/− mice were significantly higher than those in the Vsx1+/+ mice (one-way ANOVA on Rank, H=16.78, p<0.001, Dunn’s method multiple comparisons, p<0.05). No significant differences were found in the retinal DOPAC levels between the Vsx1+/+ and C57BL/6J strains. B: Although the dopamine (DA) levels were similar between the 129S1/Sv Vsx1+/+ and Vsx1−/− genotypes, the levels were significantly elevated in C57BL/6J compared with the Vsx1+/+ strain (one-way ANOVA, F(2,28)=3.76, p<0.05, Holm-Sidak multiple comparisons, p<0.05). C: The DOPAC/DA ratios were similar between the two genotypes on the 129S1/Sv background. However, the ratios were significantly lower for the C57BL/6J mice compared to the Vsx1+/+ mice (one-way ANOVA on Ranks, H=16.66, p<0.001, Dunn’s method multiple comparisons, p<0.05).