Molecular Vision: Alexander, Mol Vis 2014; 20:1253-1257. Table 2

Table 2. Frequency of Heterozygosity for p.Gly119Arg.

Studies	Controls	AMD	Odds Ratio	95% Confidence intervals
van de Ven et al.	1/3937 (0.025%)	20/3567 (0.56%)	22.20	2.98–164.49
This study	1/627 (0.16%)	7/521 (1.34%)	8.47	1.04–69.00
*Southampton*	1/389 (0.25%)	3/422 (0.71%)	(p=0.027)
*Guernsey*	0/238 (0%)	4/99 (4.04%)

The results of our present study demonstrate a much higher frequency of heterozygosity for p.Gly119Arg in both cases and controls than in the cohort reported by van de Ven. Of note is that our sub-cohort from Guernsey has a particularly high frequency of p.Gly119Arg heterozygosity in affected individuals compared to our sub-cohort from the mainland. The p value was calculated for Fishers Exact Test of the whole cohort.