Table 3 of Contreras, Mol Vis 2014; 20:105-116.


Table 3. Allelic association of SNPs in CFH, ARMS2, C2, CFB and C3 genes to AMD in Mexicans.

Gene SNP
(Allele) Allele frequency (%) Association results
Cases

n=273
Healthy
controls

n=201
Healthy and
 population
 controls

n=481
Healthy controls* Healthy and population controls
OR
(CI 0.95) p-value
(p-value†) OR
(CI 0.95) p-value
(p-value†)
CFH rs1410996
(T)

rs1061170
(C)
32.0

26.9
47.1

15.7
48.5

15.0
0.55
(0.39-0.77)

2.26
(1.51-3.37)
4.57E-04
(3.20E-03)

6.66E-05
(4.66E-04)
0.50 (0.40-0.63)

1.96
(1.49-2.58)
6.81E-09
(4.77E-08)

1.02E-06
(7.14E-06)
ARMS2 rs10490924
(T) 53.9 27.6 24.4 2.40
(1.77-3.26) 1.59E-08
(1.11E-07) 3.09 (2.48-3.86) 5.42E-23
(3.79E-22)
C2 rs547154
(A) 3.0 5.0 5.4 0.48 (0.22-1.04) 6.20E-02
(NS) 0.54 (0.30-0.94) 3.12E-02
(NS)
CFB rs4151667
(A) 0.7 1.8 2.3 0.26 (0.06-1.03) 5.52E-02
(NS) 0.34 (0.12-1.00) 5.06E-02
(NS)
C3 rs1047286
(T)

rs2230199
(G)
11.1

12.1
5.6

5.0
4.8

5.9
2.15
(1.13-4.07)

2.60 (1.37-4.92)
1.89E-02
(NS)

3.23E-03
(2.26E-02)
2.48 (1.64-3.75)

2.15 (1.48-3.13)
1.59E-05
(1.11E-04)

6.28E-05
(4.40E-04)