Table 3 of
Contreras, Mol Vis 2014; 20:105-116. Table 3 of
Contreras, Mol Vis 2014; 20:105-116.
Table 3. Allelic association of SNPs in CFH, ARMS2, C2, CFB and C3 genes to AMD in Mexicans.
| Gene | SNP (Allele) | Allele frequency (%) | Association results | |||||
|---|---|---|---|---|---|---|---|---|
| Cases n=273 |
Healthy controls n=201 |
Healthy and population controls n=481 |
Healthy controls* | Healthy and population controls | ||||
| OR (CI 0.95) | p-value (p-value†) | OR (CI 0.95) | p-value (p-value†) | |||||
| CFH | rs1410996
(T)
rs1061170 (C) |
32.0 26.9 |
47.1 15.7 |
48.5 15.0 |
0.55
(0.39-0.77) 2.26 (1.51-3.37) |
4.57E-04
(3.20E-03)
6.66E-05 (4.66E-04) |
0.50
(0.40-0.63) 1.96 (1.49-2.58) |
6.81E-09
(4.77E-08)
1.02E-06 (7.14E-06) |
| ARMS2 | rs10490924 (T) | 53.9 | 27.6 | 24.4 | 2.40 (1.77-3.26) | 1.59E-08 (1.11E-07) | 3.09 (2.48-3.86) | 5.42E-23 (3.79E-22) |
| C2 | rs547154 (A) | 3.0 | 5.0 | 5.4 | 0.48 (0.22-1.04) | 6.20E-02 (NS) | 0.54 (0.30-0.94) | 3.12E-02 (NS) |
| CFB | rs4151667 (A) | 0.7 | 1.8 | 2.3 | 0.26 (0.06-1.03) | 5.52E-02 (NS) | 0.34 (0.12-1.00) | 5.06E-02 (NS) |
| C3 | rs1047286
(T)
rs2230199 (G) |
11.1
12.1 |
5.6 5.0 |
4.8
5.9 |
2.15
(1.13-4.07) 2.60 (1.37-4.92) |
1.89E-02
(NS)
3.23E-03 (2.26E-02) |
2.48
(1.64-3.75)
2.15 (1.48-3.13) |
1.59E-05
(1.11E-04)
6.28E-05 (4.40E-04) |