Figure 3 of
Wang, Mol Vis 1996;
2:3.Figure 3 of
Wang, Mol Vis 1996;
2:3.
Figure 3. The nucleotide sequence of PDEalpha cDNA from canine retina (GenBank accession number U52868), and the deduced amino acid sequence
The position of the nucleotides and the deduced amino acids are indicated on the right. The two extra amino acids that are inserted in comparison to human and mouse sequences are shown in bold italics [Ala (849), Gly (850)]. The stop codon (TAA) is marked with asterisks (***), and the sequence motif (ATTAAA) present at the two polyadenylation sites is boldfaced. The 3'-untranslated region (UTR) of the larger transcript is shown in red to where a poly (A) tail containing 20 'A's is added (not shown) in the smaller transcript.
CTTGCAGGTCGACACTAGTGGATCCAAAGAATTCGGCACGAGAAAACACCTCCTGACTCT 60
GTCTTGCCCCCAGCTATAGACCTTCCCTGGGCAGGCCAGCTTTAGGCTCTCCTGGGAAGT 120
AGCCAGCGGGATTCCAGTC ATG GGT GAG GTG ACA GCA GAG CAG GTG GAG 169
Met Gly Glu Val Thr Ala Glu Gln Val Glu 10
AAG TTC CTG GAC TCG AAT ATT ATC TTT GCC AAA CAG TAC TAC AAC 214
Lys Phe Leu Asp Ser Asn Ile Ile Phe Ala Lys Gln Tyr Tyr Asn 25
CTC CGC TAC CGG GCC AAG GTC ATC TCA GAC ATG CTG GGG GCC AAG 259
Leu Arg Tyr Arg Ala Lys Val Ile Ser Asp Met Leu Gly Ala Lys 40
GAG GCA GCG GTG GAC TTC AGC AAC TAC CAC TCG CTG AGC AGT GTG 304
Glu Ala Ala Val Asp Phe Ser Asn Tyr His Ser Leu Ser Ser Val 55
GAG GAG AGT GAA ATC ATC TTT GAC CTC CTG CGA GAC TTC CAG GAG 349
Glu Glu Ser Glu Ile Ile Phe Asp Leu Leu Arg Asp Phe Gln Glu 70
AAT TTG CAG GCC GAG AGA TGC ATC TTC AAT GTC ATG AAG AAG CTG 394
Asn Leu Gln Ala Glu Arg Cys Ile Phe Asn Val Met Lys Lys Leu 85
TGC TTC CTC CTT CAG GCA GAT CGC ATG AGC CTG TTC ATG TAC AGG 439
Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu Phe Met Tyr Arg 100
GTC CGA AAT GGC ATC GCA GAG CTA GCC ACC CGG CTC TTC AAT GTC 484
Val Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu Phe Asn Val 115
CAC AAG GAT GCT GTC CTT GAG GAA TGC CTG GTG GCG CCC GAC TCA 529
His Lys Asp Ala Val Leu Glu Glu Cys Leu Val Ala Pro Asp Ser 130
GAG ATT GTG TTC CCC CTG GAC ATG GGT GTG GTG GGT CAC GTT GCC 574
Glu Ile Val Phe Pro Leu Asp Met Gly Val Val Gly His Val Ala 145
CAC TCT AAA AAG ATC GCC AAC GTC GTC AAC ACA GAA GAG GAT GAG 619
His Ser Lys Lys Ile Ala Asn Val Val Asn Thr Glu Glu Asp Glu 160
CAT TTC TGT GAC TTT GTG GAC ACC CTC ACT GAG TAC CAG ACC AAG 664
His Phe Cys Asp Phe Val Asp Thr Leu Thr Glu Tyr Gln Thr Lys 175
AAC ATC CTG GCT TCC CCC ATA ATG AAT GGG AAG GAC GTA GTG GCA 709
Asn Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala 190
GTA ATC ATG GCT GTG AAT AAA GTG GAC GAG CCC CAC TTC ACC AAG 754
Val Ile Met Ala Val Asn Lys Val Asp Glu Pro His Phe Thr Lys 205
AGA GAT GAA GAG ATT CTT CTC AAG TAC CTC AAT TTT GCA AAC CTA 799
Arg Asp Glu Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu 220
ATC ATG AAG GTA TAC CAC CTG AGT TAC CTA CAC AAT TGC GAG ACT 844
Ile Met Lys Val Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr 235
CGG CGT GGC CAG ATA CTG CTG TGG TCT GGG AGC AAA GTC TTT GAA 889
Arg Arg Gly Gln Ile Leu Leu Try Ser Gly Ser Lys Val Phe Glu 250
GAG CTT ACG GAC ATC GAG AGG CAG TTC CAC AAG GCC CTG TAC ACA 934
Glu Leu Thr Asp Ile Glu Arg Gln Phe His Lys Ala Leu Tyr Thr 265
GTC CGG GCC TTC CTC AAC TGT GAC AGA TAT TCT GTG GGA CTC TTA 979
Val Arg Ala Phe Leu Asn Cys Asp Arg Tyr Ser Val Gly Leu Leu 280
GAC ATG ACC AAG CAG AAG GAA TTT TTT GAT GTG TGG CCA GTC CTG 1024
Asp Met Thr Lys Gln Lys Glu Phe Phe Asp Val Try Pro Val Leu 295
ATG GGG GAG GCT CCA CCC TAT TCT GGT CCC AGG ACT CCG GAT GGA 1069
Met Gly Glu Ala Pro Pro Tyr Ser Gly Pro Arg Thr Pro Asp Gly 310
AGG GAA ATC AAC TTT TAC AAG GTC ATT GAC TAT ATC CTA CAC GGC 1114
Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp Tyr Ile Leu His Gly 325
AAA GAA GAC ATC AAA GTA ATC CCG AAT CCA CCT CCT GAT CAT TGG 1159
Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro Pro Asp His Try 340
GCT TTA GTA AGT GGT CTG CCC ACT TAT GTT GCC CAG AAT GGC CTG 1204
Ala Leu Val Ser Gly Leu Pro Thr Tyr Val Ala Gln Asn Gly Leu 355
ATT TGC AAC ATC ATG AAT GCA CCT GCA GAG GAC TTT TTT GCA TTC 1249
Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe Ala Phe 370
CAG AAA GAG CCT CTG GAT GAG TCT GGA TGG ATG ATT AAG AAT GTC 1294
Gln Lys Glu Pro Leu Asp Glu Ser Gly Try Met Ile Lys Asn Val 385
CTT TCT TTG CCA ATT GTG AAC AAG AAG GAG GAA ATT GTT GGG GTG 1339
Leu Ser Leu Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 400
GCC ACG TTT TAC AAT CGC AAA GAT GGA AAA CCC TTT GAT GAA ATG 1384
Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met 415
GAT GAG ACC CTC ATG GAG TCT TTG GCT CAA TTC CTG GGC TGG TCC 1429
Asp Glu Thr Leu Met Glu Ser Leu Ala Gln Phe Leu Gly Try Ser 430
GTC TTA AAT CCT GAT ACT TAC GAG TCA ATG AAC AGA CTT GAA AAC 1474
Val Leu Asn Pro Asp Thr Tyr Glu Ser Met Asn Arg Leu Glu Asn 445
AGG AAG GAT ATT TTC CAG GAC ATG GTA AAA TAC CAC GTG AAG TGT 1519
Arg Lys Asp Ile Phe Gln Asp Met Val Lys Tyr His Val Lys Cys 460
GAC AAT GAA GAG ATC CAG AAA ATC CTG AAA ACC AGA GAG GTG TAT 1564
Asp Asn Glu Glu Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr 475
GGG AAG GAG CCG TGG GAG TGC GAG GAA GAG GAA CTC GCT GAG ATC 1609
Gly Lys Glu Pro Try Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile 490
CTG CAA GGA GAG CTG CCA GAT GCA GAG AAA TAT GAA ATC AAT AAA 1654
Leu Gln Gly Glu Leu Pro Asp Ala Glu Lys Tyr Glu Ile Asn Lys 505
TTC CAC TTC AGC GAC TTG CCC CTG ACC GAA CTG GAG CTG GTG AAA 1699
Phe His Phe Ser Asp Leu Pro Leu Thr Glu Leu Glu Leu Val Lys 520
TGT GGG ATA CAG ATG TAC TAT GAG CTC AAA GTG GTG GAT AAA TTT 1744
Cys Gly Ile Gln Met Tyr Tyr Glu Leu Lys Val Val Asp Lys Phe 535
CAC ATT CCT CAG GAG GCC CTG GTG CGC TTC ATG TAC TCG CTG AGC 1789
His Ile Pro Gln Glu Ala Leu Val Arg Phe Met Tyr Ser Leu Ser 550
AAG GGC TAC CGC AGG ATC ACC TAC CAC AAC TGG CGG CAC GGC TTC 1834
Lys Gly Tyr Pro Arg Ile Thr Tyr His Asn Try Arg His Gly Phe 565
AAC GTG GGG CAG ACC ATG TTC TCC TTG CTG GTG ACC GGA AAG CTG 1879
Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val Thr Gly Lys Leu 580
AAG CGA TAC TTC ACA GAC CTA GAG GCC TTG GCC ATG GTC ACC GCT 1924
Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met Val Thr Ala 595
GCC TTC TGC CAT GAC ATT GAC CAC AGA GGC ACC AAC AAT CTC TAC 1969
Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 610
CAG ATG AAG TCC CAG AAC CCA CTG GCC AAG CTC CAT GGG TCC TCC 2014
Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser 625
ATC TTG GAA AGA CAC CAC TTG GAG TTC GGC AAA ACG TTG CTG CGA 2059
Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 640
GAT GAG AGC CTG AAT ATC TTT CAA AAC CTC AAT CGC AGG CAG CAC 2104
Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His 655
GAG CAC GCC ATC CAC ATG ATG GAC ATA GCA ATC ATT GCC ACA GAC 2149
Glu His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp 670
CTC GCC CTG TAT TTC AAG AAG AGG ACA ATG TTC CAA AAG ATC GTG 2194
Leu Ala Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val 685
GAT CAG TCT AAA ACA TAT GAA ACT CAG CAG GAG TGG ACA CAG TAC 2239
Asp Gln Ser Lys Thr Tyr Glu Thr Gln Gln Glu Try Thr Gln Tyr 700
ATG ATG CTG GAG CAG ACA CGG AAG GAA ATT GTT ATG GCC ATG ATG 2284
Met Met Leu Glu Gln Thr Arg Lys Glu Ile Val Met Ala Met Met 715
ATG ACC GCC TGT GAT CTC TCA GCC ATC ACC AAG CCC TGG GAG GTG 2329
Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Try Glu Val 730
CAG AGT AAG GTA GCT CTA CTG GTT GCT GCC GAA TTC TGG GAA CAA 2374
Gln Ser Lys Val Ala Leu Leu Val Ala Ala Glu Phe Try Glu Gln 745
GGT GAC CTG GAG CGC ACA GTG CTG CAG CAG AAT CCC ATT CCC ATG 2419
Gly Asp Leu Glu Arg Thr Val Leu Gln Gln Asn Pro Ile Pro Met 760
ATG GAC AGG AAC AAG GCA GAT GAA CTC CCC AAG CTT CAA GTC GGC 2464
Met Asp Arg Asn Lys Ala Asp Glu Leu Pro Lys Leu Gln Val Gly 775
TTC ATT GAC TTT GTT TGC ACC TTT GTC TAC AAG GAA TTC TCC CGT 2509
Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys Glu Phe Ser Arg 790
TTC CAC GAG GAG ATC ACT CCC ATG CTG GAT GGG ATC ACC AAC AAC 2554
Phe His Glu Glu Ile Thr Pro Met Leu Asp Gly Ile Thr Asn Asn 805
CGC AAG GAG TGG AAG GCG CTC GCC GAT GAG TAC GAC ACC AAG ATG 2599
Arg Lys Glu Try Lys Ala Leu Ala Asp Glu Tyr Asp Thr Lys Met 820
AAG GCC CTG GAG GAG GAG AAG CAG AAG CAG CAG ACA GCC AAG CAA 2644
Lys Ala Leu Glu Glu Glu Lys Gln Lys Gln Gln Thr Ala Lys Gln 835
GGG GCG GCA GGA GAT CAG CCG GGG GGC AAC CCC AGC CCG GCC GGG 2689
Gly Ala Ala Gly Asp Gln Pro Gly Gly Asn Pro Ser Pro Ala Gly 850
GGC GCA CCT GCA TCC AAG TCC TGC TGC ATC CAG TAA CGCTGCCTGGCA 2737
Gly Ala Pro Ala Ser Lys Ser Cys Cys Ile Gln *** 861
TCAGCTGCACCGAATGGTACCACCCTTCCTGGAAAGAGACCACCCAAGCCAGCAGAAAAC 2797
CAAAACCCTGCTTGTGAAGTAAAATAGTAATCGGATTTGAAAGCTGGGAGAGAATTTAGC 2857
TTACTTTCATCTAGTGGTTTTTGAACATTTTTTCAGTTTTGAATACTTTTTACTGAGCTA 2917
AAACCAACATTCTAGCTTTAATAGACATCAATTAAACATTTAATTAAGGCCAAGTTCATC 2977
TGCTTGCTTAGAATCATTTTCACTCTTATACTTCCATTTTATGATTTCTTATAACAATTG 3037
TCTAGCATCCTCAAAAGTAGAGAATTGTTCAGTGAATCCCTCCTCCTCATCACCCAGATT 3097
CCAATATCAGGGTTTTGCCCCATTTGCTTCATCCATTCTTTTACATTTCTTTCGCATTTT 3157
TTTCTTAGCTGAAGTGAAGTATTTTCTTTATTAAATTGATGGTCTTTTTTCTTTTTTTAA 3217
AAAAAAAAAAAAAAAA 3233
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