Figure 6. Effect of γ-secretase inhibitor on ocular hypertension induced by Ad-sCD44. One eye of BALB/cJ mice was injected intravitreally with 6×10⁷ pfu Ad-sCD44 at day 0. The contralateral eye was uninjected. On days 12 through 15 (indicated by gray horizontal bar), a 1% solution of a γ-secretase inhibitor (GSI) or vehicle was topically applied to mice eyes. Results are expressed as mean ± SEM (n=6 for the injected groups, n=12 for control). The statistical results are: *p<0.05, **p<0.01 versus the vehicle group by Student’s t-test.