Table 7 of
Chen, Mol Vis 2013; 19:944-954.
Table 7. Association of Complement factor H SNPs with AREDS grading of early ARM
| SNP | Genotype Frequency | Association | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | CON | ARM Grade 1 | ARM Grade 2 | ARM Grade 3 | ARM Grade 1 | ARM Grade 2 | ARM Grade 3 | ||||||||
| N | % | N | % | N | % | N | % | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||
| rs3753394 | TT | 49 | 31.2 | 20 | 27.4 | 26 | 36.1 | 5 | 38.5 | 1.22 | 0.312 | 0.85 | 0.415 | 1.07 | 0.863 |
| TC | 74 | 47.1 | 31 | 42.5 | 33 | 45.8 | 4 | 30.8 | (0.83 - 1.8) | (0.57 - 1.25) | (0.48 - 2.35) | ||||
| CC | 34 | 21.7 | 22 | 30.1 | 13 | 18.1 | 4 | 30.8 | |||||||
| rs800292 | GG | 51 | 32.5 | 21 | 28.8 | 28 | 38.9 | 6 | 46.2 | 1.22 | 0.328 | 0.91 | 0.641 | 1.02 | 0.963 |
| GA | 79 | 50.3 | 33 | 45.2 | 30 | 41.7 | 3 | 23.1 | (0.82 - 1.83) | (0.61 - 1.35) | (0.44 - 2.29) | ||||
| AA | 27 | 17.2 | 19 | 26 | 14 | 19.4 | 4 | 30.8 | |||||||
| rs1061170 | CC | 144 | 91.7 | 65 | 89 | 69 | 95.8 | 12 | 92.3 | 1.43 | 0.453 | 0.5 | 0.29 | 0.96 | 0.969 |
| CT | 13 | 8.3 | 8 | 11 | 3 | 4.2 | 1 | 7.7 | (0.54 - 3.62) | (0.11 - 1.61) | (0.05 - 5.58) | ||||
| TT | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||
| rs2274700 | CC | 49 | 31.2 | 18 | 24.7 | 25 | 34.7 | 5 | 38.5 | 1.39 | 0.125 | 1.01 | 0.958 | 0.9 | 0.807 |
| CT | 84 | 53.5 | 36 | 49.3 | 33 | 45.8 | 6 | 46.2 | (0.92 - 2.11) | (0.67 - 1.53) | (0.36 - 2.12) | ||||
| TT | 24 | 15.3 | 19 | 26 | 14 | 19.4 | 2 | 15.4 | |||||||
| rs3753396 | GG | 39 | 24.8 | 15 | 20.5 | 22 | 30.6 | 5 | 38.5 | 1.37 | 0.125 | 0.89 | 0.556 | 0.92 | 0.84 |
| AG | 83 | 52.9 | 33 | 45.2 | 34 | 47.2 | 4 | 30.8 | (0.92 - 2.08) | (0.59 - 1.32) | (0.4 - 2.09) | ||||
| AA | 35 | 22.3 | 25 | 34.2 | 16 | 22.2 | 4 | 30.8 | |||||||
| rs1065489 | TT | 39 | 24.8 | 15 | 20.5 | 21 | 29.2 | 5 | 38.5 | 1.37 | 0.129 | 0.9 | 0.624 | 0.76 | 0.524 |
| GT | 82 | 52.2 | 33 | 45.2 | 35 | 48.6 | 5 | 38.5 | (0.92 - 2.06) | (0.6 - 1.35) | (0.32 - 1.74) | ||||
| GG | 36 | 22.9 | 25 | 34.2 | 16 | 22.2 | 3 | 23.1 | |||||||