Figure 1. Linkage disequilibrium of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 and complement factor H
single nucleotide polymorphisms.
A: The single nucleotide polymorphisms (SNPs) rs
10490924,
rs11200638, and
rs2672598 in age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (
ARMS2/HTRA1) form a haplotype block in a 6 kb genomic region. (
B) The SNPs
rs10490924,
rs11200638, and
rs2672598 in complement factor H (
CFH) form a long haplotype block in a 26 kb genomic region according to the criteria of the confidence intervals, an algorithm
proposed by Gabriel et al. [
20]. The solid line with an arrow indicates the transcription direction.