Molecular Vision: Karring, Mol Vis 2013; 19:861-876. Table 2

Table 2. Categorization of proteins in groups.

Amyloidogenic proteins	Non-fibrillar amyloid-associated proteins	Structural extracellular matrix proteins	Other extracellular matrix proteins	Structural intracellular proteins	Other intracellular proteins	Membrane-bound proteins
TGFBIp	Serum amyloid P-component	Collagen α-1(I)	Serum albumin	Keratin 15	α-enolase	Desmoglein-1
Apolipoprotein A-IV	Clusterin	Collagen α-2(I)	S100-A7^a	Keratin 13	Histone H2A type 1-A
Apolipoprotein A-I	Serine protease HtrA1	Keratocan	Thioredoxin^a	Keratin 3	ALDH3A1
Ig kappa light chain, C and V-III	Apolipoprotein E	Collagen α-3(VI)	Angiopoietin-related protein 7	Keratin 12	52 kDa Ro protein
Lysozyme C	Prostaglandin-H2 D-isomerase^a	Collagen α-1(VI)	Cytokine-like protein 1	Keratin 75	Hornerin
S100-A8	Complement component C9	Collagen α-2(VI)	Prolactin-inducible protein	Keratin 4	Desmoplakin
S100-A9	Decorin	Lumican	PEDF	Keratin 71	Filaggrin-2
Lactotransferrin	Apolipoprotein D	Collagen α-2(V)	Kallikrein-14	Keratin 1b	CAND1
	Cystatin-A	Collagen α-1(III)		Keratin 23
	Vitronectin	Collagen α-1(V)		Glial fibrillary acidic protein
	Biglycan	Collagen α-1(VIII)
	Glia-derived nexin	Prolargin
	Complement component C3	Collagen α-4(IV)
	Thrombospondin-4	Collagen α-1(XII)
8 (13%)	14 (22%)	14 (22%)	8 (13%)	10 (16%)	8 (13%)	1 (2%)

The 63 distinct proteins identified in the amyloid deposits from the LCD type 1 variant with the A546D mutation in TGFBI are categorized according to their functional roles and cellular localization reported in current literature. The group with amyloidogenic proteins includes those that cause primary amyloidosis in other diseases. Non-fibrillar amyloid-associated proteins include those that are reported to bind or colocalize with amyloid deposits in other diseases, but are not themselves amyloidogenic in vivo. Structural extracellular matrix proteins include collagens and proteoglycans (leucine-rich repeat proteins), while other extracellular matrix proteins are categorized together. Structural intracellular proteins include intermediate filament proteins such as keratins, while other intracellular proteins are categorized together. Membrane-bound proteins are categorized in one group. The proteins in each group are listed according to relative abundances. The lowest row indicates the number of proteins in each group with the corresponding percentages in brackets. ^a: the protein can be both extra- and intracellular.