Molecular Vision: Karring, Mol Vis 2013; 19:861-876. Table 1

Table 1. Abundant proteins in the corneal amyloid deposits, periamyloid corneal tissue, and healthy corneal stroma.

Amyloid deposits (LCD type 1 variant)		Periamyloid corneal tissue (LCD type 1 variant)		Healthy stroma (normal cornea)
Protein	mol %	Protein	mol %	Protein	mol %
TGFBIp	39.34	Type I collagen	22.33 (α-1) 14.07 (α-2)	TGFBIp	14.44
Type I collagen	21.16 (α-1) 6.47 (α-2)	TGFBIp	19.05	Type I collagen	12.75 (α-1) 8.49 (α-2)
Serum amyloid P-component	2.27	Clusterin	6.56	Decorin	6.53
Keratocan	2.27	Apolipoprotein A-IV	5.5	Keratocan	6.28
Apolipoprotein A-IV	1.66	Phospholipase A2	4.87	Type VI collagen	3.57 (α-1) 3.02 (α-3) 2.49 (α-2)
Apolipoprotein A-I	1.38	Apolipoprotein D	3.6	Serum albumin	3.49
Clusterin	1.35	Serum amyloid P-component	2.96	Apolipoprotein A-I	2.28
Type VI collagen	1.26 (α-3) 1.13 (α-1) 0.82 (α-2)	Serum albumin	2.12	Immunoglobulin gamma heavy chain (IgG)	1.81
Serine protease HtrA1	1.22	Keratin 12	2.12	Immunoglobulin kappa light chain (IgK)	1.77
Serum albumin	1.19	Keratocan	1.8	Lumican	1.41

The table shows the ten most abundant proteins in the amyloid deposits and periamyloid corneal tissue from the LCD type 1 variant, and healthy corneal stroma listed according to their mol % values. The different types of collagen are ranked according to the collagen chain with the highest emPAI-based molar fraction. The collagen chain species are indicated in brackets after the mol % values. Proteins shown in bold have at least a twofold increase in molar fraction compared to the healthy stroma.