Figure 6. Curcumin-induced microRNAs in ARPE-19 cells. Following two criteria of statistical significance (p<0.05) and fold change (FC) (≥ or ≤2), the quantitative real-time polymerase chain reaction (qRT-PCR) array revealed five microRNAs (miRNAs) that were upregulated in cells treated with 20 μM curcumin for 6 h. The miRNAs have been reported to target angiotensin II type 1 receptor (AT1R), nuclear factor-kappa B (NF-κB), platelet-derived growth factor β (PDGFβ), and vascular endothelial growth factor (VEGF). Data represent mean±SEM from three separate samples. Data represent mean±SEM from three separate samples. *p<0.05 versus control, **p<0.001 versus control, #p<0.05 versus H2O2.