Table 2 of
Xin, Mol Vis 2013; 19:526-535. Table 2 of
Xin, Mol Vis 2013; 19:526-535.
Table 2. Meta-analysis for the association between TNF-α −308G/A (rs1800629) polymorphisms and risks of open angle glaucoma
| Contrast | All relevant articles were included (n=14) | Articles deviated for HWE were excluded (n=10)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | M b | I2(%) | P valuec | OR | 95%CI | M b | I2(%) | P valuec | ||
| A versus G | HTG | 1.374 | 0.825–2.290 | R | 82.6 | 0.000 | 1.660 | (1.033–2.667)* | R | 75.0 | 0.001 |
| NTG | 0.680 | 0.384–1.204 | F | 0.0 | 0.000 | 1.005 | 0.321–3.140 | F | – | – | |
| EXG | 1.957 | 0.515–7.442 | R | 94.6 | 0.445 | 1.181 | 0.373–3.732 | R | 87.4 | 0.000 | |
| Caucasian | 1.005 | 0.596–1.695 | R | 72.5 | 0.012 | 1.005 | 0.596–1.695 | R | 72.5 | 0.012 | |
| Asian | 1.591 | 0.853–2.966 | R | 89.4 | 0.000 | 1.947 | (1.097–3.456)* | R | 73.3 | 0.002 | |
| ALL | 1.379 | 0.877–2.170 | R | 87.4 | 0.000 | 1.440 | 0.958–2.164 | R | 76.8 | 0.000 | |
| AA versus GG | HTG | 1.047 | 0.245–4.467 | R | 75.1 | 0.003 | 1.688 | 0.404–7.055 | R | 71.0 | 0.016 |
| NTG | 0.174 | 0.010–3.184 | F | – | – | – | – | – | – | — | |
| EXG | 7.918 | (1.473–42.558)* | R | 58.5 | 0.090 | 2.896 | 0.653–12.841 | F | 0.0 | 0.338 | |
| Caucasian | 0.896 | 0.296–2.714 | F | 28.4 | 0.248 | 0.896 | 0.296–2.714 | F | 28.4 | 0.248 | |
| Asian | 1.793 | 0.446–7.211 | R | 80.2 | 0.000 | 3.277 | 0.716–14.990 | R | 74.1 | 0.021 | |
| ALL | 1.585 | 0.525–4.787 | R | 73.6 | 0.000 | 2.133 | 0.745–6.105 | R | 56.1 | 0.044 | |
| GA versus GG | HTG | 1.349 | 0.843–2.159 | R | 70.2 | 0.003 | 1.580 | (1.006–2.477)* | R | 59.0 | 0.032 |
| NTG | 0.848 | 0.461–1.557 | F | 0.0 | 0.734 | 1.005 | 0.319–3.165 | F | – | – | |
| EXG | 1.684 | 0.506–5.608 | R | 91.1 | 0.000 | 1.075 | 0.344–3.360 | R | 85.3 | 0.001 | |
| Caucasian | 1.028 | 0.571–1.849 | R | 73.5 | 0.010 | 1.028 | 0.571–1.849 | R | 73.5 | 0.010 | |
| Asian | 1.549 | 0.914–2.625 | R | 78.3 | 0.000 | 1.688 | 0.941–3.030 | R | 62.9 | 0.019 | |
| ALL | 1.359 | 0.916–2.018 | R | 76.9 | 0.000 | 1.341 | 0.883–2.036 | R | 69.8 | 0.000 | |
| AA/GA versus GG | HTG | 1.421 | 0.865–2.334 | R | 75.6 | 0.000 | 1.713 | (1.107–2.651)* | R | 60.4 | 0.027 |
| NTG | 0.752 | 0.414–1.367 | F | 0.0 | 0.567 | 1.005 | 0.319–3.165 | F | – | – | |
| EXG | 1.921 | 0.488–7.560 | R | 93.7 | 0.000 | 1.130 | 0.346–3.689 | F | 86.7 | 0.001 | |
| Caucasian | 1.018 | 0.571–1.815 | R | 73.5 | 0.010 | 1.018 | 0.571–1.815 | R | 73.5 | 0.010 | |
| Asian | 1.652 | 0.897–3.041 | R | 85.5 | 0.000 | 1.949 | (1.140–3.332)* | R | 60.1 | 0.028 | |
| ALL | 1.421 | 0.907–2.226 | R | 83.6 | 0.000 | 1.440 | 0.949–2.815 | R | 71.8 | 0.000 | |