Figure 2. Upregulation of miR-146a and miR-26a in vitreus humor from uveal melanoma samples. Box and Whisker plot of miR-146a (A) and miR-26a (B) expression in vitreus humor (VH) from three different pathological conditions: macular hole, retinal detachment, and uveal melanoma. Values on the y-axis are reported as the relative quantity of microRNAs (miRNAs) compared to serum. Thin line: miRNA expression on normal retinal cells; thick line: miRNA expression in formalin-fixed, paraffin-embedded tissues from uveal melanoma patients. Differential expression of miRNAs in patients with uveal melanoma compared to the other pathological classes was evaluated with the Wilcoxon rank-sum test (p<0.05).