Figure 4. Overexpression of spliced X-box binding protein 1 partially reverses the inhibition of retinal pigment epithelium cell proliferation by quinotrierixin. ARPE-19 cells were transducted with adenovirus expressing spliced XBP1 or LacZ as control and then treated with quinotrierixin 0.5 μM for 24 h. A: Phase contrast images are presented. B-C: Cell proliferation was determined with MTT (B) or cell counting (C). Quantitative data are expressed as mean±SD (n=4 in each group). **p<0.01 versus control, ††p<0.01 versus QT.