Table 2 of
Yuan, Mol Vis 2013; 19:374-383. Table 2 of
Yuan, Mol Vis 2013; 19:374-383.
Table 2. Meta-analysis of the association of Val62Ile polymorphism with AMD.
| Polymorphism | study | No. of studies | sample size (No.) | Test of association | Heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|---|
| case | control | OR (95%CI) | Z | P value | Model | I2% | |||
| GG+GA avs AA | Overall | 14 | 4438 | 6099 | 2.28 (1.48–3.52) | 3.74 | 0.0002 | bR | 88 |
| Asian | 10 | 2771 | 3043 | 2.28 (1.75–2.97) | 6.13 | <0.00001 | R | 46 | |
| Caucasian | 4 | 1667 | 3056 | 2.58 (0.84–7.91) | 1.66 | 0.1 | R | 91 | |
| GA versus AA | Overall | 14 | 1917 | 4485 | 1.58 (1.13–2.19) | 2.71 | 0.007 | R | 75 |
| Asian | 10 | 1259 | 1983 | 1.64 (1.30–2.08) | 4.13 | <0.00001 | cF | 27 | |
| Caucasian | 4 | 658 | 2502 | 1.56 (0.70–3.45) | 1.09 | 0.28 | R | 79 | |
| GG versus AA | Overall | 14 | 3003 | 3530 | 2.90 (1.95–4.30) | 5.28 | <0.00001 | R | 78 |
| Asian | 10 | 1720 | 1578 | 3.18 (2.37–4.28) | 7.66 | <0.00001 | R | 52 | |
| Caucasian | 4 | 1283 | 1952 | 2.83 (0.76–10.62) | 1.54 | 0.12 | R | 90 | |
| G versus A | Overall | 14 | 8876 | 12,198 | 1.77 (1.43–2.21) | 5.13 | <0.00001 | R | 89 |
| Asian | 10 | 5542 | 6086 | 1.85 (1.63–2.09) | 9.77 | <0.00001 | R | 46 | |
| Caucasian | 4 | 3334 | 6112 | 1.73 (0.91–3.30) | 1.66 | 0.1 | R | 95 | |