Figure 4. Rimonabant inhibited the H2O2-induced increase in intracellular ROS and activated the H2O2-induced decrease in intracellular superoxide dismutase (SOD) in RPE cells. A: RPE cells were pretreated with rimonabant (0 to 1 μM) for 15 min before being exposed to H2O2 (200 μM) for 24 h. Intracellular ROS was measured with the DCF-DA assay. *p<0.05 versus H2O2. B: SOD activity was assayed with a commercially available assay kit. *p<0.05 versus control (no H2O2 no rimonabant). #p<0.05 versus H2O2. The statistical test of A is one way ANOVA, n=4 per group. In the B, the test is two way ANOVA, n=4 per group.