Figure 4. Rimonabant inhibited the H₂O₂-induced increase in intracellular ROS and activated the H₂O₂-induced decrease in intracellular superoxide dismutase (SOD) in RPE cells. A: RPE cells were pretreated with rimonabant (0 to 1 μM) for 15 min before being exposed to H₂O₂ (200 μM) for 24 h. Intracellular ROS was measured with the DCF-DA assay. *p<0.05 versus H₂O₂. B: SOD activity was assayed with a commercially available assay kit. *p<0.05 versus control (no H₂O₂ no rimonabant). #p<0.05 versus H₂O₂. The statistical test of A is one way ANOVA, n=4 per group. In the B, the test is two way ANOVA, n=4 per group.