Figure 5. Downregulation of pentraxin 3 (PTX3) production by extracellular-signal-regulated kinases (ERK) 1/2 and/or nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling inhibitors. ARPE-19 cells were stimulated with interleukin 1 beta (IL-1β; A), tumor necrosis factor alpha (TNF-α; B), or interferon gamma (IFN-γ; C) in the absence or presence of mitogen activating protein (MAP) kinase and NF-κB signaling inhibitors. After 60 h, supernatants were harvested and assessed for PTX3 production. Results are shown as means±SD of three independent experiments. *p<0.05 versus vehicle.