Figure 1. Production of pentraxin 3 (PTX3) by stimulation of inflammatory cytokines, interleukin 1 beta (IL-1β), and tumor necrosis
factor alpha (TNF-α), in human RPE cells. ARPE-19 cells were stimulated with IL-1β (A), TNF-α (B), or IFN-γ (C) dose-dependently. After 60 h, supernatants were harvested and assessed for PTX3 production. ARPE-19 cells were incubated
for various time periods in the absence or presence of IL-1β (D) and TNF-α (E). Supernatants were harvested and measured for PTX3 production at the indicated time. Values are mean±SD. Results are representative
for three independent experiments. *p<0.05 versus vehicle.