Figure 7. Real-time polymerase chain reaction analysis of the proapoptotic gene, Bax, from the optic nerves and retinas of three ocular models: (A) Glaucoma (B) ONTX and (C) NMDA retinal toxicity. Bax expression increased significantly in the optic nerves (ONs) and retinas of all three models. The peak intraocular pressure (IOP) was significantly correlated with Bax expression in ONs and retinas (D,E: r=0.64, 0.69, p<0.05 respectively), as was the mean IOP (F,G: r=0.53, 0.81, p<0.05, respectively). Values are expressed as fold change of gene expression compared to a calibrator (endogenous control, β-actin); n=5–7 rats at each time point. Data represent means±standard error of the mean (SEM); ^#significantly higher at p<0.05 than ON controls, **significantly higher at p<0.05 than controls.