Figure 4. Matrix metalloproteinases (MMP)-10 and integrin α3 protein levels in the corneas of rats fed normal chow (lane 1) or 50% galactose in the absence (lane 2) or presence (lane 3) of aldose reductase inhibitor were analyzed by immunoblotting. The protein expression level of MMP-10 was enhanced by exposure to 50% galactose, while integrin α3 expression decreased. These changes were normalized with the treatment of aldose reductase inhibitor. No significant change was found in the expression levels of integrin α6 or β4. The bar graphs illustrate the intensities of the bands relative to β-actin. The values are mean±standard error of the mean; *p<0.05.