Figure 3 of Jaramillo-Rangel, Mol Vis 2013; 19:2468-2476.


Figure 3. Phenotypic analysis of eyes from 2-month-old mice expressing human p53 transgene (Tgp53) in the lens, in the presence or absence of p53 E3 ubiquitin protein ligase homolog. Non-transgenic mice harboring a homozygous mutation at the p53 E3 ubiquitin protein ligase homolog (Mdm2) locus (mdm2−/−/Tgp530/0) show a normal eye size. In contrast, the mdm2−/−/Tgp53t/0 mice have microphthalmia and closed eyelids. Microphthalmia is rescued by the concomitant presence of an Mdm2 allele (mdm2+/−/Tgp53t/0). For comparison, the enucleated eyes are shown in the bottom panel.