Figure 6. Retinal ganglion cell soma protection in wild-type and hypoxia-inducible factor-1α retinal ganglion cell-knockout mice with experimental glaucoma by prior repetitive hypoxic preconditioning. Quantification of NeuN–positive soma in the retinal ganglion cell layer following 3 weeks of intraocular hypertension in the four experimental groups, normalized to fellow eyes (black bars) are shown. Note that repetitive hypoxic preconditioning (RHP) provided protection against the glaucomatous loss of the retinal ganglion cell (RGC) soma in wild-type (WT; green) and hypoxia-inducible factor-1α retinal ganglion cell-knockout (HIF-1α RGC-KO; blue) mice. *p<0.05 versus fellow eye; #p<0.05 versus non-preconditioned glaucoma in the same genotype. Means±standard error of the mean (SEM).