Molecular Vision: Zanon-Moreno, Mol Vis 2013; 19:231-242. Table 2

Table 2. Genotypic frequencies of the SLC23A2, TTPA, TAP and GPX4 SNPs in primary open glaucoma (POAG) cases and controls and association with POAG risk. Crude and multivariate estimations

Genes	SNP		Genotype frequencies (%)						Independent analysis by SNP					Multivariate model with all SNPs
		Alleles*	Cases			Controls			Independent analysis by SNP					Multivariate model with all SNPs
		(1/2)	1/1	1/2	2/2	1/1	1/2	2/2	p1	OR (95%CI)**	p2	OR * (95% CI)**	p3	OR^ (95%CI)	p4
SLC23A2	rs1279683	A/G	11.7	47.4	40.9	16.9	54.2	28.9	0.014	1.70 (1.17–2.47)	0.005	2.11 (1.34–3.32)	0.001	2.47 (1.62–3.77)	<0.001
TTPA	rs6994076	T/A	22.0	46.5	31.5	22.2	49.8	28	0.673	1.19 (0.80–1.75)	0.393	1.17 (0.79–1.75)	0.429	1.38 (0.92–2.10)	0.122
TAP/SEC14L2	rs737723	G/C	19.9	47.6	32.5	28.5	50.2	21.3	0.009	1.78 (1.18–2.69)	0.006	1.73 (1.13–2.65)	0.011	2.24 (1.44–3.48)	<0.001
GPX4	rs757228	G/A	29.9	50.0	20.1	24	53.3	22.7	0.325	0.85 (0.55–1.32)	0.477	0.82 (0.52–1.28)	0.371	0.80 (0.50–1.27)	0.337

SNP: Single nucleotide polymorphism *Allele 1 is the ancestral allele according to the National Center for Biotechnology Information Database (dbSNP). Allele 2 is the variant allele **: Unadjusted odds ratio (OR) and 95% confidence interval (CI) for homozygous subject for the variant allele [2] in comparison with the reference category (homozygotes and heterozygotes for the ancestral allele) for each SNP in the separate genetic analyses. Separate model for each SNP; ***: OR adjusted for sex, age, BMI, smoking and drinking did not change the statistical significance. ^: OR for each SNP obtained in the multivariate model including at the same time the four SNPs analyzed. Further adjustment for sex, age, BMI, smoking and drinking did not change the statistical significance. p1: p value obtained in the corresponding Chi-square test for the comparison of the genotype distribution between cases and controls (three groups) p2: p value obtained in the crude logistic regression analysis for the OR for each SNP in the individual genetic analyses p3: p value in obtained in the multivariate logistic regression after adjustment for sex, age, BMI, tobacco smoking and drinking for each SNP in the individual genetic analysis. p4: p value obtained in the crude logistic regression analysis for the OR for each SNP in the multivariate genetic analysis including all SNPs in the multivariate model. Presented p values are uncorrected for multiple comparisons. Considering the correction for multiple comparisons, an uncorrected p value <0.0125 was considered to be statistically significant