Table 3 of
Whitmore, Mol Vis 2013; 19:2274-2297. Table 3 of
Whitmore, Mol Vis 2013; 19:2274-2297.
Table 3. Genes previously associated with AMD by genetic studies.
| Ensembl ID | Symbol | Mean AMD | Mean Control | Fold change | Raw p value | FDR adj. P value | Name |
|---|---|---|---|---|---|---|---|
| ENSG00000100156 | SLC16A8 | 8.26 | 7.88 | 1.31 | 0.0129 | 0.4358 | solute carrier family 16, member 8 (monocarboxylic acid transporter 3) [43] |
| ENSG00000166278 | C2 | 7.49 | 7.19 | 1.24 | 0.1434 | 0.6643 | complement component 2 [43,45,46] |
| ENSG00000125730 | C3 | 8.80 | 8.55 | 1.19 | 0.1226 | 0.6470 | complement component 3 [40,47-49] |
| ENSG00000000971 | CFH | 9.64 | 9.43 | 1.16 | 0.2662 | 0.7440 | complement factor H [41,50-52] |
| ENSG00000100234 | TIMP3 | 11.37 | 11.22 | 1.11 | 0.3122 | 0.7823 | TIMP metallopeptidase inhibitor 3 [40,49,53,54] |
| ENSG00000243649 | CFB | 7.93 | 7.81 | 1.09 | 0.4199 | 0.8396 | complement factor B [43,45,46] |
| ENSG00000205403 | CFI | 8.93 | 8.84 | 1.07 | 0.6688 | 0.9296 | complement factor I [43,55] |
| ENSG00000225830 | ERCC6 | 7.34 | 7.29 | 1.03 | 0.7487 | 0.9492 | excision repair cross-complementing rodent repair deficiency, complementation group 6 [56] |
| ENSG00000137331 | IER3 | 7.72 | 7.67 | 1.03 | 0.8162 | 0.9636 | immediate early response 3 [43] |
| ENSG00000168386 | FILIP1L | 8.14 | 8.17 | −1.02 | 0.8496 | 0.9718 | filamin A interacting protein 1-like [43] |
| ENSG00000144810 | COL8A1 | 9.15 | 9.20 | −1.04 | 0.7052 | 0.9370 | collagen, type VIII, alpha 1 [43,57] |
| ENSG00000166033 | HTRA1 | 8.36 | 8.50 | −1.10 | 0.4118 | 0.8344 | HtrA serine peptidase 1 [58-60] |
| ENSG00000104689 | TNFRSF10A | 6.88 | 7.12 | −1.18 | 0.0136 | 0.4398 | tumor necrosis factor receptor superfamily, member 10a [43,61] |
| ENSG00000112715 | VEGFA | 7.11 | 7.36 | −1.19 | 0.0735 | 0.5904 | vascular endothelial growth factor A [12,62] |