Table 2 of Whitmore, Mol Vis 2013; 19:2274-2297.

Table 2. Differentially expressed genes in early AMD versus control samples.

Ensembl ID Symbol Mean AMD Mean Control Fold change Raw p value FDR adj. P value Name
ENSG00000138207 RBP4 9.01 7.92 2.12 0.0089 0.4149 retinol binding protein 4, plasma
ENSG00000198759 EGFL6 7.78 6.77 2.01 0.0089 0.4149 EGF-like-domain, multiple 6
ENSG00000158201 ABHD3 8.01 7.13 1.84 0.0044 0.3607 abhydrolase domain containing 3
ENSG00000186480 INSIG1 9.25 8.44 1.76 0.0024 0.3582 insulin induced gene 1
ENSG00000112972 HMGCS1 8.39 7.58 1.76 0.0095 0.4149 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ENSG00000116791 CRYZ 9.20 8.39 1.75 0.0002 0.2057 crystallin, zeta (quinone reductase)
ENSG00000135324 MRAP2 7.41 6.61 1.75 0.0006 0.2515 melanocortin 2 receptor accessory protein 2
ENSG00000165124 SVEP1 8.16 7.37 1.74 0.0052 0.3792 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
ENSG00000149485 FADS1 9.22 8.43 1.73 0.0035 0.3582 fatty acid desaturase 1
ENSG00000112394 SLC16A10 7.43 6.67 1.70 0.0001 0.1976 solute carrier family 16, member 10 (aromatic amino acid transporter)
ENSG00000109452 INPP4B 7.41 6.66 1.69 0.0031 0.3582 inositol polyphosphate-4-phosphatase, type II, 105 kDa
ENSG00000091137 SLC26A4 7.80 7.04 1.69 0.0030 0.3582 solute carrier family 26, member 4
ENSG00000134824 FADS2 9.08 8.34 1.67 0.0089 0.4149 fatty acid desaturase 2
ENSG00000153790 C7orf31 8.06 7.32 1.67 0.0089 0.4149 chromosome 7 open reading frame 31
ENSG00000251606 CTD-2215E18.1 8.28 7.55 1.66 0.0006 0.2515 Uncharacterized protein
ENSG00000178896 EXOSC4 9.03 8.32 1.63 0.0039 0.3582 exosome component 4
ENSG00000125931 CITED1 8.14 7.47 1.60 0.0013 0.3582 Cbp/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 1
ENSG00000184270 HIST2H2AB 8.04 7.41 1.55 0.0034 0.3582 histone cluster 2, H2ab
ENSG00000121316 PLBD1 7.40 6.77 1.54 0.0001 0.1976 phospholipase B domain containing 1
ENSG00000134202 GSTM3 8.04 7.42 1.53 0.0095 0.4149 glutathione S-transferase mu 3 (brain)
ENSG00000165996 PTPLA 7.81 7.21 1.51 0.0000 0.1157 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
ENSG00000147459 DOCK5 7.25 6.65 1.51 0.0062 0.4088 dedicator of cytokinesis 5
ENSG00000169084 DHRSX 7.68 7.09 1.51 0.0035 0.3582 dehydrogenase/reductase (SDR family) X-linked
ENSG00000070961 ATP2B1 7.75 8.37 −1.53 0.0041 0.3582 ATPase, Ca2+ transporting, plasma membrane 1
ENSG00000186260 MKL2 8.50 9.12 −1.54 0.0038 0.3582 MKL/myocardin-like 2
ENSG00000125834 STK35 7.66 8.29 −1.54 0.0057 0.4062 serine/threonine kinase 35
ENSG00000155749 ALS2CR12 6.77 7.39 −1.54 0.0004 0.2281 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
ENSG00000115350 POLE4 8.41 9.04 −1.55 0.0028 0.3582 polymerase (DNA-directed), epsilon 4 (p12 subunit)
ENSG00000130559 CAMSAP1 7.34 7.98 −1.56 0.0028 0.3582 calmodulin regulated spectrin-associated protein 1
ENSG00000132932 ATP8A2 6.46 7.13 −1.59 0.0030 0.3582 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ENSG00000181004 BBS12 7.07 7.75 −1.60 0.0098 0.4191 Bardet-Biedl syndrome 12
ENSG00000149294 NCAM1 7.06 7.74 −1.60 0.0068 0.4149 neural cell adhesion molecule 1
ENSG00000254528 RP11–728F11.4 7.98 8.67 −1.62 0.0018 0.3582
ENSG00000156194 PPEF2 7.19 7.89 −1.63 0.0024 0.3582 protein phosphatase, EF-hand calcium binding domain 2
ENSG00000132026 RTBDN 6.52 7.25 −1.66 0.0032 0.3582 retbindin
ENSG00000080511 RDH8 6.82 7.56 −1.66 0.0046 0.3607 retinol dehydrogenase 8 (all-trans)
ENSG00000139220 PPFIA2 6.46 7.21 −1.68 0.0043 0.3582 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
ENSG00000082126 MPP4 7.27 8.02 −1.68 0.0088 0.4149 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
ENSG00000153944 MSI2 6.61 7.36 −1.68 0.0064 0.4141 musashi homolog 2 (Drosophila)
ENSG00000239474 KBTBD10 7.54 8.30 −1.69 0.0025 0.3582 kelch repeat and BTB (POZ) domain containing 10
ENSG00000131711 MAP1B 8.24 9.04 −1.74 0.0002 0.2057 microtubule-associated protein 1B
ENSG00000102755 FLT1 9.15 9.97 −1.76 0.0059 0.4088 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
ENSG00000172519 OR10H5 6.51 7.33 −1.77 0.0011 0.3582 olfactory receptor, family 10, subfamily H, member 5
ENSG00000059804 SLC2A3 7.88 8.77 −1.86 0.0003 0.2094 solute carrier family 2 (facilitated glucose transporter), member 3
ENSG00000128052 KDR 8.08 8.99 −1.89 0.0015 0.3582 kinase insert domain receptor (a type III receptor tyrosine kinase)
ENSG00000198515 CNGA1 8.87 9.90 −2.05 0.0005 0.2515 cyclic nucleotide gated channel alpha 1
ENSG00000108370 RGS9 6.12 7.19 −2.10 0.0059 0.4088 regulator of G-protein signaling 9
ENSG00000074621 SLC24A1 6.62 7.71 −2.13 0.0062 0.4088 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
ENSG00000143995 MEIS1 7.49 8.59 −2.14 0.0000 0.1172 Meis homeobox 1
ENSG00000149489 ROM1 7.80 8.94 −2.20 0.0036 0.3582 retinal outer segment membrane protein 1
ENSG00000146350 C6orf170 6.09 7.26 −2.25 0.0001 0.2057 chromosome 6 open reading frame 170
ENSG00000114279 FGF12 6.20 7.38 −2.27 0.0004 0.2281 fibroblast growth factor 12
ENSG00000134183 GNAT2 6.85 8.08 −2.35 0.0036 0.3582 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
ENSG00000158445 KCNB1 6.13 7.37 −2.37 0.0047 0.3608 potassium voltage-gated channel, Shab-related subfamily, member 1
ENSG00000118473 SGIP1 7.24 8.50 −2.38 0.0004 0.2281 SH3-domain GRB2-like (endophilin) interacting protein 1
ENSG00000182985 CADM1 7.50 8.86 −2.58 0.0047 0.3608 cell adhesion molecule 1
ENSG00000078018 MAP2 7.25 8.63 −2.60 0.0016 0.3582 microtubule-associated protein 2
ENSG00000205683 DPF3 5.87 7.26 −2.62 0.0012 0.3582 D4, zinc and double PHD fingers, family 3
ENSG00000047617 ANO2 6.73 8.16 −2.70 0.0043 0.3582 anoctamin 2
ENSG00000158234 FAIM 6.41 7.96 −2.92 0.0020 0.3582 Fas apoptotic inhibitory molecule
ENSG00000118402 ELOVL4 6.78 8.35 −2.97 0.0039 0.3582 ELOVL fatty acid elongase 4
ENSG00000111837 MAK 6.18 7.76 −3.00 0.0020 0.3582 male germ cell-associated kinase
ENSG00000203756 C6orf191 5.94 7.56 −3.07 0.0092 0.4149 chromosome 6 open reading frame 191
ENSG00000114349 GNAT1 5.42 7.12 −3.24 0.0034 0.3582 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
ENSG00000100362 PVALB 6.18 7.88 −3.26 0.0084 0.4149 parvalbumin
ENSG00000152578 GRIA4 5.84 7.55 −3.28 0.0031 0.3582 glutamate receptor, ionotrophic, AMPA 4
ENSG00000132639 SNAP25 6.20 7.96 −3.38 0.0087 0.4149 synaptosomal-associated protein, 25 kDa
ENSG00000148798 INA 5.36 7.17 −3.49 0.0074 0.4149 internexin neuronal intermediate filament protein, alpha
ENSG00000130561 SAG 6.03 7.84 −3.51 0.0049 0.3688 S-antigen; retina and pineal gland (arrestin)
ENSG00000112619 PRPH2 6.61 8.50 −3.73 0.0014 0.3582 peripherin 2 (retinal degeneration, slow)
ENSG00000116703 PDC 5.93 7.86 −3.83 0.0096 0.4149 phosducin
ENSG00000163914 RHO 7.26 9.23 −3.93 0.0051 0.3754 rhodopsin
ENSG00000132915 PDE6A 5.87 7.88 −4.02 0.0045 0.3607 phosphodiesterase 6A, cGMP-specific, rod, alpha
ENSG00000185518 SV2B 5.43 7.60 −4.50 0.0045 0.3607 synaptic vesicle glycoprotein 2B
ENSG00000112706 IMPG1 5.29 7.50 −4.62 0.0060 0.4088 interphotoreceptor matrix proteoglycan 1

Genes were filtered based on at least 50% fold change between AMD and control and raw p value <0.01.

Whitmore, Mol Vis 2013; 19:2274-2297. http://www.molvis.org/molvis/v19/2274

©2013 Molecular Vision http://www.molvis.org/molvis/

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