Figure 3. Identification of a novel mutation (c.606+1 G>A) in the major intrinsic protein (MIP) gene in a Chinese family with autosomal dominant congenital cataract. A: DNA sequencing results of an unaffected family member (upper panel) and an affected family member (lower panel). Results showed a heterozygous mutation (c.606+1 G>A) at the donor of splice site of intron 3 of the MIP (black arrow) gene. The black vertical line shows the normal exon 3-intron 3 donor splice site.