Table 2 of
Yanshole, Mol Vis 2013; 19:2196-2208. Table 2 of
Yanshole, Mol Vis 2013; 19:2196-2208.
Table 2. Post-translational modifications identified for proteins in SOIcs and SOIar for 12-week-old OXYS lens.
| Spot Nº (Crystallin) | Sequence coverage, % | Abundance, % | Modification | |||||
|---|---|---|---|---|---|---|---|---|
| Wistar | OXYS | Oxidation (M) | Acetylation (N-term) | Deamidation (N, Q) | Phosphory-lation (S, T) | |||
| Cataract-specific spots of interest (SOIcs) | ||||||||
| 2 (αA) | 59 | ND | 0.3±0.3 | M1 | M1 | T4 | ||
| 3 (αA) | 87 | 0.17±0.09 | 0.83±0.16 | M1, M138 | M1 | T4 | ||
| 4 (αA) | 89 | 0.13±0.14 | 0.61±0.24 | M1, M138 | M1 | T4 | ||
| 5 (αA) | 89 | 1.26±0.37 | 3.06±1.28 | M1 | M1 | N123 | T4 | |
| 9 (αA) | 82 | 0.46±0.35 | 1.32±0.54 | M1, M138 | M1 | N123, Q126 | T4 | |
| 10 (αA) | 71 | 1.29±0.37 | 3.58±0.86 | M1, M138 | M1 | T4 | ||
| 11 (αA) | 78 | 0.34±0.17 | 0.78±0.39 | M1 | M1 | N123, Q126 | T4 | |
| 13 (αA) | 48 | ND | 0.30±0.07 | M1 | M1 | T4 | ||
| 21 (αA) | 87 | 0.84±0.25 | 1.59±0.57 | M1 | M1 | T4 | ||
| 24 (αB) | 65 | ND | 0.30±0.14 | M1 | M1 | S19 | ||
| 36 (αB) | 73 | 0.49±0.27 | 0.85±0.13 | M1, M68 | M1 | N146 | ||
| 46 (αB) | 65 | ND | 0.19±0.05 | M1 | M1 | N146 | S19 | |
| 56 (αB) | 70 | ND | 0.52±0.13 | M1 | M1 | N146 | ||
| 8 (βA4) | 98 | ND | 0.23±0.05 | Q112, N114, Q187, Q189 | ||||
| 22 (βA4) | 96 | ND | 0.66±0.37 | Q112, N114 | ||||
| 18 (βB1) | 72 | ND | 0.13±0.07 | M135, M162, M224 | ||||
| 32 (βB1) | 67 | ND | 0.91±0.30 | M135, M162 | ||||
| 61 (βB2) | 93 | 0.86±0.33 | 1.71±0.71 | N174, Q185 | ||||
| Age-related spots of interest (SOIar) | ||||||||
| 20 (βA4) | 91 | 4.51±1.80 | 2.90±0.86 | M132 | Q63, Q65, Q66, Q112, N114, Q187, Q189 | |||
| 80 (γA) | 63 | 4.61±2.51 | 2.17±1.39 | M136, M160 | ||||
| 86 (γA) | 66 | 11.5±2.61 | 5.17±1.11 | M136, M160, M124 | ||||
| 84 (γC) | 58 | 4.32±1.57 | 1.93±0.96 | M102 | ||||
| 73 (γE) | 58 | 6.89±1.67 | 3.65±1.98 | M44, M102, M160 | N50, N161 | |||