Figure 2. Refractive error changes (difference between right and left eyes) in wild-type, rd1, and rd10 mice after form deprivation, starting at 4 weeks of age. A: Wild-type (WT) mice developed a significant myopic shift in goggled eyes by 1 week that steadily increased across the 5 weeks of form deprivation (FD; repeated-measures analysis of variance [RM-ANOVA] F_(5,253)=3.49, p=0.005). B: Rd1 mice developed a larger myopic shift than naïve controls after 1 week of goggling that further increased after 2 weeks of FD (RM-ANOVA, F_(2,111)=6.97, p=0.002). C: Rd10 mice developed a dramatic myopic shift that was significantly different from that of the controls after 2 weeks of goggling (RM-ANOVA, F_(2,81)=9.12, p<0.001). D: After 2 weeks of goggling, the rd1 and rd10 mice had significantly greater myopic shifts than the WT mice (ANOVA, F_(2,118)=8.69, p<0.001; WT: n=28 goggled, n=21 naïve controls; rd1: n=25 goggled, n=17 naïve controls; rd10: n=14 goggled, n=14 naïve controls). Symbols and bars represent average±standard error of the mean (SEM). Post-hoc analysis: ^#p<0.05; *p<0.02; ⁺p<0.005; **p<0.001.