Molecular Vision: Aljohani, Mol Vis 2013; 19:1966-1984. Table 3

Table 3. Common sphingoid base species between control and glaucomatous aqueous humor.

Lipid Species*	m/z**	Control			Glaucoma
Lipid Species*	m/z**	Average normalized lipid amount	Standard error of mean	Donor frequency	Average normalized lipid amount	Standard error of mean	Fold change	Donor frequency
(4E,6E,d14:2) sphingosine	239.6	48.79	29.22	8	0.95	0.52	0.020	10
6-hydroxysphingosine	312.3	22.90	15.67	5	0.00			1
C16 Sphinganine	277.4	54.53	36.54	9	6.31	5.85	0.116	10
C17 Sphinganine	291.7	70.48	66.93	10	1.55	0.92	0.022	10
iso (4E,15-methyl-d16:1) sphingosine	280.6	0.02		1	0.13	0.03	5.736	3
N,N,N-trimethyl-sphingosine	346.0	92.13	65.31	9	0.86	0.57	0.009	9
N,N-dimethylsphingosine	332.1	73.67	68.76	10	2.14	2.01	0.029	10
Obscuraminol A	280.2	52.84	25.33	4	0.01	0.00		3
Penaresidin A	334.0	0.37	0	1	1.73	0.67	4.627	2
Penazetidine A	373.9	1.93	1.42	7	10.99	9.06	5.705	7
Phytosphingosine	322.0	10.59	7.73	10	0.23	0.10	0.022	9
R-Dysidazirine	309.4	0.58	0.16	2	54.11		94.020	1

*The lipid species identification is based on Lipidmaps database, used as a *.csv file for bioinformatic analyses with MZmine 2.9 program. ** A representative mass/charge ratio from normal samples is presented (variations in m/z was reconciled by MZmine 2.9). Average standard normalized dataset is presented here. Lipids in this class that were identified by our approach of analyses but are not bonafide entities for mammalian systems/humans were excluded from this list. Lipids that has not been clearly determined to originate in non-mammalian species or those that are known to exist in mammals/human despite their abundant presence in plants and fungi such as Phytosphingosine (Human metabolomics database ID: HMDB04610) were retained. For some lipid species identified, standard deviation value could not be calculated due to lack of presence in all samples. Average normalized lipid amount is pmol lipid per species/µg protein. Fold change is the ratio relative to control.