Table 2 of
Zhang, Mol Vis 2013; 19:1913-1924. Table 2 of
Zhang, Mol Vis 2013; 19:1913-1924.
Table 2. Meta-analysis of the TNF gene polymorphisms in BD
| Polymorphisms | Population | Number of studies | Sample size | Test of association | Test of heterogeneity | Egger’s test (P) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case control | OR (95%CI) | Z | P | Model | χ2 | P | I2 (%) | |||||
| TNF −308A/G | Overall | 11 | 1232 | 1397 | 0.730(0.608–0.877) | 3.37 | 0.001 | F | 13.28 | 0.208 | 24.7 | 0.317 |
| A versus G allele | Asian | 5 | 654 | 779 | 0.676(0.511–0.894) | 2.75 | 0.006 | F | 4.24 | 0.375 | 5.7 | 0.066 |
| Caucasian | 5 | 458 | 506 | 0.833(0.627–1.108) | 1.25 | 0.21 | F | 7.85 | 0.11 | 47 | 0.565 | |
| African | 1 | 120 | 112 | 0.638(0.400–1.017) | 1.89 | 0.059 | NA | NA | NA | NA | NA | |
| TNF −238A/G | Overall | 8 | 842 | 938 | 1.512(1.155–1.979) | 3.01 | 0.003 | F | 5.96 | 0.544 | 0 | 0.002 |
| A versus G allele | 8a | NA | NA | 1.521(1.159–1.995) | 3.03 | NA | NA | NA | NA | NA | NA | |
| Asian | 3 | 413 | 548 | 1.421(0.876–2.303) | 1.42 | 0.154 | F | 0.66 | 0.72 | 0 | 0.627 | |
| Caucasian | 4 | 309 | 278 | 1.556(1.074–2.253) | 2.34 | 0.019 | F | 5.2 | 0.158 | 42.3 | 0.02 | |
| 4a | NA | NA | 1.574(1.083–2.288) | 2.38 | NA | NA | NA | NA | NA | NA | ||
| African | 1 | 120 | 112 | 1.548(0.790–3.033) | 1.27 | 0.203 | NA | NA | NA | NA | NA | |
| TNF −1031C/T | Overall | 7 | 738 | 964 | 1.549(1.190–2.015) | 3.26 | 0.001 | R | 13.54 | 0.035 | 55.7 | 0.89 |
| C versus T allele | Asian | 3 | 415 | 548 | 1.203(0.967–1.496) | 1.65 | 0.098 | F | 2.11 | 0.348 | 5.3 | 0.542 |
| Caucasian | 3 | 234 | 259 | 2.171(1.581–2.981) | 4.79 | <0.001 | F | 2.01 | 0.366 | 0.6 | 0.575 | |
| African | 1 | 99 | 103 | 1.654(1.098–2.493) | 2.41 | 0.016 | NA | NA | NA | NA | NA | |
| TNF −857T/C | Overall | 4 | 533 | 660 | 0.758(0.593–0.968) | 2.22 | 0.027 | F | 0.45 | 0.93 | 0 | 0.949 |
| T versus C allele | Asian | 3 | 326 | 310 | 0.757(0.583–0.983) | 2.09 | 0.037 | F | 0.45 | 0.799 | 0 | 0.974 |
| African | 1 | 120 | 112 | 0.763(0.375–1.553) | 0.75 | 0.456 | NA | NA | NA | NA | NA | |
| TNF −863A/C | Overall | 3 | 489 | 570 | 1.101(0.707–1.713) | 0.43 | 0.671 | R | 6.31 | 0.043 | 68.3 | 0.45 |
| A versus C allele | Asian | 2 | 369 | 458 | 1.091(0.551–2.158) | 0.25 | 0.803 | R | 6.15 | 0.013 | 83.7 | NA |
| African | 1 | 120 | 112 | 1.082(0.623–1.878) | 0.28 | 0.779 | NA | NA | NA | NA | NA | |
| TNF −376A/G | Overall | 3 | 326 | 310 | 0.438(0.188–1.024) | 1.9 | 0.057 | F | 0.24 | 0.889 | 0 | 0.756 |
| A versus G allele | Caucasian | 2 | 206 | 198 | 0.476(0.142–1.597) | 1.2 | 0.23 | F | 0.19 | 0.66 | 0 | NA |
| African | 1 | 120 | 112 | 0.405(0.123–1.334) | 1.49 | 0.137 | NA | NA | NA | NA | NA | |