Molecular Vision: Atan, Mol Vis 2013; 19:184-195. Table 3

Table 3. Associations between IIU and the TNFA-308 and TNFA-238 loci are most compatible with an additive (allelic model)

Locus	IIU patients	Healthy controls	X²	Degrees of freedom	p value	p_c value	Odds ratio for minor allele (95% CI)
TNFA −308 (rs1800629)
Genotype frequency AA/AG/GG	3/24/17	2/24/66	13.84	2	0.001	0.019	-
Allele frequency A/G	30/58	28/156	12.64	1	0.00038	0.0042	2.9 (1.6–5.2)
TNFA −238 (rs361525)
Genotype frequency AA/AG/GG	0/16/28	1/6/85	18.36	2	<0.0010	<0.019	-
Allele frequency A/G	16/72	8/176	14.16	1	0.00017	0.0019	4.9 (2.0–11.9)

Modeling the genetic association revealed an underlying allelic (additive) model with the minor alleles, TNFA-308A and TNFA-238A, associated with disease. Dominant and recessive models were not significant. Statistical analyses of genetic model used the Pearson X² test with 2-tailed probability values in PLINK with Bonferroni correction for the number of loci (n=19). Genotype associations were determined using the Fisher exact test in SPSS with Bonferroni correction (n=19). Odds ratios were calculated in Open Epi. Abbreviations: p value, uncorrected probability value; p_c, Bonferroni corrected p value (p_c=p x11); X², Chi-square test; CI, confidence intervals.