Molecular Vision: Atan, Mol Vis 2013; 19:184-195. Table 2

Table 2. Associations between IIU and HLA, TNF and IL10 loci.

Locus	Chromosome	X²	Degrees of freedom	p value	p_c value
IL10 −3545	1	0.129	2	0.7195	NS
IL10 −2849	1	1.186	2	0.2762	NS
IL10 −1082	1	0.343	2	0.5579	NS
IL10 −819	1	0.426	2	0.5138	NS
IL10 +434	1	0.021	2	0.8850	NS
IL10 +504	1	0.004	2	0.9472	NS
IL10 +1847	1	0.610	2	0.4346	NS
LTA+252	6	2.992	2	0.0837	NS
TNFA −308	6	10.99	2	0.0009	0.0171
TNFA −238	6	11.54	2	0.0007	0.0133
TNFA +488	6	0.494	2	0.4821	NS
TNFd	6	1.688	10	0.8904	NS
HLA A	6	18.94	15	0.2165	NS
HLA Cw	6	13.15	12	0.3581	NS
HLA B	6	27.06	22	0.2088	NS
HLA Bw	6	0.001	1	0.9701	NS
HLA DRB1	6	28.45	12	0.0048	NS
HLA DR3–5	6	1.194	3	0.7953	NS
HLA DQB	6	15.22	6	0.0254	NS

IIU is significantly associated with the TNFA-308 and TNFA-238 loci. There were associations with the HLA DRB1 and HLA DQB loci that lost significance after Bonferroni correction. Statistical analyses used the Likelihood ratio χ² test in UNPHASED with 2-tailed probability values and Bonferroni correction for the number of loci (n=19). Abbreviations: NS, not significant with a p value>0.05; p value, uncorrected probability value; p_c, Bonferroni corrected p value (p_c=p x19); X², Chi-square test.