Figure 3. Increasing of peripheral blood mononuclear cell (PBMC) toll-like receptor 2 (TLR2) and TLR3 expressions and their reactivity to TLR ligands in wet age-related macular degeneration (AMD) patients. PBMCs were stimulated with PGN (5 μg/ml) and PolyI;C (50 μg/ml) respectively for 48 h. The PBMCs of the wet AMD patients (n=11) produced much higher IL-6 and IL-8 than the controls (n=11) in response to PGN, and much higher IL-6 than the controls in response to PolyI:C (A, B). The productions of MCP-1and VEGF showed no significant difference between the two groups (C, D) Mann–Whitney test, *p<0.05, **p<0.01.