Figure 5. Predictive promoter model–based genome-wide target selection focused on the co-occurrence of HMX1-BS pairs. A: Simultaneous possible combinations of HMX1-BS pairs allowed by the predictive promoter model (PPM) with three or four HMX1-BSs. Pairs are identified according to HMX1-BSs numbers. B: Flowchart of the mouse and human PPM-based selections filtering according to HMX1-BS pairs counting. ^#See Figure 4 for details regarding the PPM-based selection process. Expression localization in the retina is indicated for genes carrying multiple HMX1-BS pairs. Significant enrichment in the axon guidance pathway is also indicated (see the text). C: Details of human and mouse EPHA6 structure in the region surrounding the transcription start site (TSS). Forward (CAAGTG) and reverse (CACTTG) HMX1-BSs are symbolized by black and white triangles, respectively. Distances (bp) between HMX1-BSs are indicated in red.