Figure 2. Elaboration and statistical validation of an Hmx1 predictive promoter model. A: Flowchart of the predictive promoter model (PPM) construction. #Location of CAAGTG motifs within proximal promoter or 5'UTR region is given in (B). B: Details of Sgcg, Tshz2, and Slc6a9 promoter structure. Forward (CAAGTG) and reverse (CACTTG) HMX1 binding sites (HMX1-BSs) are symbolized by black and white triangles, respectively. The H letter indicates an HMX1-BS that is strictly conserved in human. C: Statistical validation of the PPM. Columns represent the percentage of promoters carrying at least 1 HMX1-BS or fitting the PPM in each group. Promoter count details are indicated for the false discovery rate (FDR)<0.1 group and the (+)-training set (FDR<0.01 group). *p<0.01, **p<0.001.