Figure 4. Intercellular adhesion molecule-1 (ICAM-1) in different grades of external limiting membrane (ELM) and inner segment-outer
segment (IS-OS) junction disruption in the study groups. Box and whisker plot showing the distribution of ICAM-1 levels in
the three grades of ELM and IS-OS junction disruption in the study groups. There was an increase in the levels of ICAM-1 with
increase in the grade of disruption. A significant difference was found between ICAM-1 levels and different grades of disruption
(p=0.0005). A significant difference was found between ICAM-1 levels in the grade 0 and grade 2 disruption (p<0.001). No significant
difference was found between grade 1 and 2 disruption. Data are shown as upper and lower quartile, median and range. Grade
0: No Disruption; Grade 1: ELM disrupted IS-OS junction intact; Grade 2: both ELM and IS-OS junction disrupted; Q1: upper
quartile; Q3: lower quartile.