Figure 8. Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 immunostaining of adult human dermal fibroblasts.
Dermal fibroblasts were derived from normal subjects with no history of glaucoma (A, C) and a family member with glaucoma 1, open angle, F (GLC1F) with primary open-angle glaucoma (POAG) carrying the synonymous
T255T mutation (B, D). Images show the colocalization of ankyrin repeat and suppressor of cytokine signaling (SOCS) box containing protein-10
(ASB10) (red) with ubiquitin (green, A, B) and histone deacetylase 6 (HDAC6, green, C, D). Nuclei were stained with 4',6-diamidino-2-phenylindole dihydrochloride (DAPI). Scale bars=20 µm.