Figure 3. Analysis of the pathogenic mutation p.G83R of the transthyretin (TTR) protein in vertebrates. A: The sequencing electropherogram shows the mutated region in a normal control (III:23) and a patient (III:21) in Family B. B: Evolutionary analysis of position 83 in the TTR protein is shown. Protein sequences of Homo sapiens (CAG33189), Pan troglodytes (NP_001009137), Mus musculus (AAH24702), Rattus norvegicus (NP_036813), Bos taurus (NP_776392), Ovis aries (NP_001009800), Sus scrofa (NP_999377), Gallus gallus (NP_990666), Xenopus laevis (NP_001081348), and Danio rerio (AAI64894) were retrieved from GenBank.