Figure 1. Pedigree and mutation analysis. A: Shown is a consanguineous Israeli Muslim Arab family segregating autosomal recessive sensorineural hearing loss (SNHL) and
retinitis pigmentosa (RP). Double lines indicate a consanguineous union. Filled symbols represent affected individuals, whereas
clear symbols represent unaffected individuals. The genotypes of each family member at the myosin VIIA (MYO7A) and the phosphodiesterase 6B, cyclic guanosine monophosphate-specific, rod, beta (PDE6B) genes are indicated. m, mutant allele; +, wt allele. B: Nucleotide sequence traces in non-carrier individuals (WT) and in affected individuals (MUT) homozygous for the c.2308delC
mutation of MYO7A or the c.1417delC mutation of PDE6B.