Figure 5. Pedigree drawing with sequence conservation of the L60 residue of RPE65. A: Pedigree drawing of family PKRP160 with haplotypes formed with chromosome 1p markers. Pedigree symbols are described in Figure 1. B: Sequence conservation of the L60 residue in other RPE65 orthologs. Primates are green, placental mammals are blue, and vertebrates are purple. The arrow points to the amino acid residue L60 that is mutated in individuals affected with retinitis pigmentosa.